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BUSCO, like Cegma, is a special tool for the field of "completeness assessment". This concerns genome assemblies, particularly ones generated de-novo, when by concentrating on a core set of genes, one can estimate how complete the assembly is by the number of the these core geens that the assembly has managed to recover.

BUSCO actually stands for "Benchmarking Universal Single-­Copy Orthologs" and labels itself as a quality measure of the assembly. Busco also means "I search" in the Spanish and Portuguese languages, in which the authors find satisfaction, as the broad goal of the tool is one of a quest for quality.