Difference between revisions of "MicroRNAs"
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Revision as of 08:10, 6 October 2017
Introduction
MicroRNAs take part in the gene silencing by being a component of ithe multi-protein RISC, the RNA-induced silencing complex which silences genes.
Relevant Papers
"Predicting effective microRNA target sites in mammalian mRNAs"
By Agarwal et al eLife 2015 , link here
- miRNA targets involve pairing the miRNA seed region with complementary site on the mRNA in question.
- A canonical site on an mRNA is the exact complement of the miRNA seed. Most but not all bindings are canonical.
- miRNAs often bind to mRNA and degrade it (i.e. represses it) so that it produces less protein.
