MicroRNAs - Revision history

Rf at 14:58, 2 February 2018

2018-02-02T14:58:56Z

Rf at 14:55, 2 February 2018

2018-02-02T14:55:37Z

Rf at 14:42, 2 February 2018

2018-02-02T14:42:00Z

Rf at 14:14, 2 February 2018

2018-02-02T14:14:35Z

Rf at 08:10, 6 October 2017

2017-10-06T08:10:28Z

Rf at 13:26, 4 October 2017

2017-10-04T13:26:20Z

Rf: Created page with "= Introduction = = Relevant Papers = == "Predicting effective microRNA target sites in mammalian mRNAs" == By Agarwal et al eLife 2015 , link [https://www.ncbi.nlm.nih.gov/p..."

2017-10-04T13:14:49Z

Created page with "= Introduction = = Relevant Papers = == "Predicting effective microRNA target sites in mammalian mRNAs" == By Agarwal et al eLife 2015 , link [https://www.ncbi.nlm.nih.gov/p..."

New page

= Introduction =

= Relevant Papers =

== "Predicting effective microRNA target sites in mammalian mRNAs" ==
By Agarwal et al eLife 2015 , link [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532895 here]

@@ Line 21: / Line 21: @@
 == mirTools paper ==
 Gives good overview of the available tools
-* paper can be found [http://www.tandfonline.com/doi/full/10.4161/rna.25193 here]
+* paper can be found [http://www.tandfonline.com/doi/full/10.4161/rna.25193 here] although their tools website seems to be down (http://centre.bioinformatics.zj.cn/mr2_dev)

← Older revision		Revision as of 14:55, 2 February 2018
Line 18:		Line 18:
	* A canonical site on an mRNA is the exact complement of the miRNA seed. Most but not all bindings are canonical.		* A canonical site on an mRNA is the exact complement of the miRNA seed. Most but not all bindings are canonical.
	* miRNAs often bind to mRNA and degrade it (i.e. represses it) so that it produces less protein.		* miRNAs often bind to mRNA and degrade it (i.e. represses it) so that it produces less protein.
		+
		+	== mirTools paper ==
		+	Gives good overview of the available tools
		+	* paper can be found [http://www.tandfonline.com/doi/full/10.4161/rna.25193 here]

@@ Line 9: / Line 9: @@
 = Tools =
-As the above description suggests, how and where a pre-microRNA olds back on itself is a critical point, and a well known which uses free energy calculations is RNAfold from the Vienna RNA package.
+As the above description suggests, how and where a pre-microRNA olds back on itself is a critical point, and a well known which uses free energy calculations is '''RNAfold''' from the Vienna RNA package.
 = Relevant Papers =

@@ Line 1: / Line 1: @@
 = Introduction =
-MicroRNAs take part in the gene silencing by being a component of ithe multi-protein RISC, the RNA-induced silencing complex which silences genes.
+MicroRNAs take part in the gene silencing by being a component of the multi-protein RISC, the RNA-induced silencing complex which silences genes.
 = Relevant Papers =

← Older revision		Revision as of 08:10, 6 October 2017
Line 1:		Line 1:
	= Introduction =		= Introduction =
		+
		+	MicroRNAs take part in the gene silencing by being a component of ithe multi-protein RISC, the RNA-induced silencing complex which silences genes.
		+

	= Relevant Papers =		= Relevant Papers =

← Older revision		Revision as of 13:26, 4 October 2017
Line 5:		Line 5:
	== "Predicting effective microRNA target sites in mammalian mRNAs" ==		== "Predicting effective microRNA target sites in mammalian mRNAs" ==
	By Agarwal et al eLife 2015 , link [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532895 here]		By Agarwal et al eLife 2015 , link [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532895 here]
		+	* miRNA targets involve pairing the miRNA seed region with complementary site on the mRNA in question.
		+	* A canonical site on an mRNA is the exact complement of the miRNA seed. Most but not all bindings are canonical.
		+	* miRNAs often bind to mRNA and degrade it (i.e. represses it) so that it produces less protein.