Difference between revisions of "MicroRNAs"
(Created page with "= Introduction = = Relevant Papers = == "Predicting effective microRNA target sites in mammalian mRNAs" == By Agarwal et al eLife 2015 , link [https://www.ncbi.nlm.nih.gov/p...") |
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== "Predicting effective microRNA target sites in mammalian mRNAs" == | == "Predicting effective microRNA target sites in mammalian mRNAs" == | ||
By Agarwal et al eLife 2015 , link [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532895 here] | By Agarwal et al eLife 2015 , link [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532895 here] | ||
| + | * miRNA targets involve pairing the miRNA seed region with complementary site on the mRNA in question. | ||
| + | * A canonical site on an mRNA is the exact complement of the miRNA seed. Most but not all bindings are canonical. | ||
| + | * miRNAs often bind to mRNA and degrade it (i.e. represses it) so that it produces less protein. | ||
Revision as of 14:26, 4 October 2017
Introduction
Relevant Papers
"Predicting effective microRNA target sites in mammalian mRNAs"
By Agarwal et al eLife 2015 , link here
- miRNA targets involve pairing the miRNA seed region with complementary site on the mRNA in question.
- A canonical site on an mRNA is the exact complement of the miRNA seed. Most but not all bindings are canonical.
- miRNAs often bind to mRNA and degrade it (i.e. represses it) so that it produces less protein.
